RNA Details
Disease Name
neurofibromatosis
Tissue
nerve
RNA Symbol
miR-193a-5p
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
microarray; qRT-PCR etc.
Target
NA
Pathway
NA
PubMed ID
Title
MicroRNAome profiling in benign and malignant neurofibromatosis type 1-associated nerve sheath tumors: evidences of PTEN pathway alterations in early NF1 tumorigenesis
Year
2013
Function
"To comprehensively characterize the role of micrornas in nf1 tumorigenesis, we analyzed 377 mirnas expression in a large panel of dermal and plexiform neurofibromas, and mpnsts. The most significantly upregulated mirna in plexiform neurofibromas was mir-486-3p that targets the major tumor suppressor gene, pten. We confirmed pten downregulation at mrna level. In plexiform neurofibromas, we also report aberrant expression of four mirnas involved in the ras-mapk pathway (mir-370, mir-143, mir-181a, and mir-145). ."